狗狗冠状病好治么？
犬冠状病毒(Canine Coronavirus， Coronaviridae)是犬的一种急性传染病，主要感染幼犬、幼猫及发育中的胎儿，引起腹泻和呕吐。 病毒对环境的抵抗力较强，能耐低温，在粪便中可存活数月至数年[1]。本病目前尚无有效疫苗可以预防[2][3]。 在自然条件下，冠状病毒可引起犬冠状病毒病（Canine coronavirus， CanCoV），临床症状类似犬细小病毒病（canine parvovirus disease， CPV-D）[4]，但通常症状较轻；也可引起猫咪的传染性肠炎（Feline infectious enteritis， FIP)[5]。
2006年英国的一篇文章报道[6]： 一项来自英格兰北部的小鼠研究指出当把两种病毒同时注射入小鼠体内时，可以观察到由冠状病毒引起的疾病有加重现象，这表明其他病毒感染可能会促进冠状病毒引发严重疾病的可能性的增加. 在这项研究中，将一种老鼠肝炎病毒与人类冠状病毒注入同一只小鼠体内后，会引起更严重的胃肠炎综合症，并延长病程.这些结果表明病毒性胃肠炎会相互增强，这为临床治疗带来了挑战性. 这种小鼠试验的结果是否适用于人尚不清楚，但是，如果冠状病毒在人类中传播的同时还感染了另一类病毒，那么冠状病毒病的严重性将会上升就并不奇怪了。另外，冠状病毒可在人体中长期存在，也可能带来潜在的威胁。
Coronaviruses are zoonotic and a leading cause of illness and death among animals worldwide [7，8]， including the common cold in humans (HCoVs)， severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002–2003 that spread to many countries causing human deaths， Middle East Respiratory SyndromeCoronavirus (MERS-CoV) in 2012 that mainly infects people from Arabia Peninsula but has now been found in several other places as well[9]. Although coronaviruses do not usually cause more than mild symptoms in humans， they can be transmitted efficiently between individuals resulting in severe diseases like SARS or MERS [10]， which have both led to large number of casualties around the world since their emergence respectively in 2002 and 2012. Currently there is no vaccination against HCoVs， SARS-CoV ， or MERS-CoV so prevention relies on strict control measures for infected patients or quarantine if necessary [11，12]. In addition to this， coronaviruses also infect wild animal species such as bats， raccoon dogs， civet cats and pangolins ， thus posing potential danger to public health by the spillover effects from these reservoir hosts into humans [7，8，13，14]. Furthermore， with globalization， the possibility increases greatly that pathogens will cross borders rapidly and may result in an outbreak anywhere at anytime due to inadequate surveillance network across continents， lack of timely information exchange and weak international collaboration mechanism ， making preparedness essential [15]. All these factors indicate that it is imperative to study all aspects of coronaviruses’ life cycle especially its interaction with host cells and virulence